オオノ　ミチヤ   OHNO MICHIYA   大野　道也    所属   朝日大学  歯学部 総合医科学講座 内科学（朝日大学病院）    職種   教授
言語種別	英語
発行・発表の年月	1994/01
形態種別	研究論文（学術雑誌）
査読	査読あり
標題	Effects of acetylsalicy acid on pulmonary vascular tone and membrane permeability in blood-perfused dog lung
執筆形態	共著
掲載誌名	J.Appl.physiol
掲載区分	国外
巻・号・頁	73,pp.2561-2569
著者・共著者	Kenjiro Kambara,Michio Arakawa,Takashi Segawa,Fumio Ando,Michiya Ohno,Aki Kano
概要	We studied the effects of acetylsalicylic acid (ASA) on pressor response, microvascular filtration coefficient (Kf), extravascular lung water, and plasma concentrations of cyclooxygenase- and 5-lipoxygenase-derived products in 21 blood-perfused dog lungs with constant flow. We conclude that pulmonary microvascular permeability is unaltered by ASA and that neither the decrease in plasma prostacyclin nor the increase in plasma sulfidopeptide leukotrienes may account for ASA-induced pulmonary vasoconstriction.