オオノ　ミチヤ   OHNO MICHIYA   大野　道也    所属   朝日大学  歯学部 総合医科学講座 内科学（朝日大学病院）    職種   教授
言語種別	英語
発行・発表の年月	2012/12
形態種別	研究論文
査読	査読あり
標題	Lanthanum Carbonate for Hyperphosphatemia in Patients on Peritoneal Dialysis
執筆形態	共著
掲載誌名	Peritoneal dialysis international: journal of the International Society for Peritoneal Dialysis 33(3
掲載区分	国外
巻・号・頁	33(3)
著者・共著者	Michiya Ohno, Hiroshige Ohashi, Hiroshi Oda, Haruko Yokoyama, Miho Okada, Mayu Nagaya, Kumiko Izumi, Hitomi Ito, Shuji Katoh
概要	Background: The efficacy of the phosphate binder lanthanum carbonate has been demonstrated for hemodialysis patients, but no studies have focused on patients undergoing continuous ambulatory peritoneal dialysis (CAPD). We evaluated whether lanthanum carbonate could control phosphate levels in patients on CAPD. Methods: In this 48-week open-label prospective study, 28 patients on CAPD with a phosphate level of 6 mg/dL or greater were given lanthanum carbonate titrated from 750 mg to 2250 mg daily to achieve a target serum phosphate level of less than 6 mg/dL. The primary efficacy endpoint was reduction of serum phosphate to less than 6 mg/dL. Serum levels of calcium and parathyroid hormone were also evaluated, as were the Ca×P product and adverse effects. Conclusions: Lanthanum carbonate is an effective phosphate binder that can control serum phosphate and Ca×P product in CAPD patients with hyperphosphatemia. Lanthanum carbonate was well tolerated in our population.