オオノ　ミチヤ   OHNO MICHIYA   大野　道也    所属   朝日大学  歯学部 総合医科学講座 内科学（朝日大学病院）    職種   教授
言語種別	英語
発行・発表の年月	1998/07
形態種別	研究論文
査読	査読あり
標題	Role of Apoptosis in the Disappearance of Infiltrated and Proliferated Interstitial Cells After Myocardial Infarction
執筆形態	共著
掲載誌名	Circulation Research
掲載区分	国外
巻・号・頁	82(11),pp.1130-1138
著者・共著者	Genzou Takemura, Michiya Ohno, Yukihiro Hayakawa, Jun Misao, Motoo Kanoh, Atsuko Ohno, Yoshihiro Uno, Shinya Minatoguchi, Takako Fujiwara, Hisayoshi Fujiwaa
概要	Myocardial infarction (MI) progresses from the acute death of myocytes and the infiltration of inflammatory cells into granulation, followed by scars. During the healing process, the myocardial interstitial cell population in the infarcted tissues increases markedly and then decreases. We postulated that apoptosis is responsible for this process. Thus, apoptosis plays an important role in the disappearance of both the infiltrated leukocytes and the proliferated interstitial cells after MI. This finding may have therapeutic implications for postinfarct ventricular remodeling through apoptosis handling during the healing stage of MI.