オオノ　ミチヤ   OHNO MICHIYA   大野　道也    所属   朝日大学  歯学部 総合医科学講座 内科学（朝日大学病院）    職種   教授
言語種別	英語
発行・発表の年月	1994/03
形態種別	研究論文（学術雑誌）
査読	査読あり
標題	Comparison of effects of dihydropyridine calucium antagonists on left ventricular systolic and diastolic performance.
執筆形態	共著
掲載誌名	J Pharmacol and Exp Ther
掲載区分	国外
巻・号・頁	268(3),pp.1232-1241
著者・共著者	Che-Ping Cheng,Toshiyuki Noda,Margarita Nordlander,Michiya Ohno,Wikkiam C,Little
概要	We compared the effects of three dihydropyridine calcium antagonists (felodipine, nifedipine and amlodipine) on left ventricular (LV) contractile performance and diastolic filling dynamics in eight conscious animals.Thus, we conclude that in conscious dogs after autonomic blockade, at dosages that produced equivalent arterial vasodilation, felodipine augmented, whereas amlodipine depressed, LV contractile performance, LV relaxation and early LV filling. Nifedipine decreased LV contractile performance but had no significant effect on LV relaxation and early LV filling.