タツミ　ジュンイチ   TATSUMI JUNICHI   辰巳　順一    所属   朝日大学  歯学部 口腔感染医療学講座 歯周病学    朝日大学  大学院 歯学研究科    職種   教授
言語種別	英語
発行・発表の年月	2024/12
形態種別	研究論文（学術雑誌）
査読	査読あり
標題	Correlation between gingival crevicu;lar fluid matrix metalloproteinases and tissue inhibitors of metalloproteinases expression and clinical parameters in periodontal disease classification (2017).
執筆形態	共著
掲載誌名	Operative Dentistry, Endodontology and Periodontology (ODEP)
掲載区分	国内
出版社・発行元	日本歯科保存学会
巻・号・頁	4(1),pp.16-24
総ページ数	9
担当範囲	企画、:研究指導，および執筆分担者
担当区分	最終著者
著者・共著者	Shimizu Y, Ohno Y, Nagase H, Imaeda N, Katsube Y, Morinaga H, and Tatsumi J.
概要	GCF contains bioactive substance such as tissue-destructive factors and has attracted attention as one of the diagnostic materials. In this study aims to assess the correlation between GCF MMP/TIMP expression etc,. The expression of MMP-8 and -9 increased after Stage III and IV and Grade B and C, while the expression of TIMP-1 and -2 showed a decreasing trend with increasing stage severity and decreased after Grade B and C. Periodontitis triggers elevated GCF volume, disrupting MMP/TIMP balance, leading to tissue destruction and compromised homeostasis. Evaluating GCF parameters could serve as an objective measure in the classification (2017) of periodontal disease.
ISSN	2436-4975