タジリカ　トシヒロ   TAJIRIKA TOSHIHIRO   田尻下　敏弘    所属   朝日大学  歯学部 総合医科学講座 外科学（朝日大学病院）    職種   准教授
言語種別	日本語
発行・発表の年月	2012/01
形態種別	研究論文
標題	Enoxaparin and fondaparinux attenuates endothelial damage in endotoxemic rats
執筆形態	共著
掲載誌名	J Trauma Acute Care Surg
巻・号・頁	72(1),177-82頁
担当範囲	症例(臨床)担当、考察
著者・共著者	Iba T, Okamoto K, Ohike T, Tajirika T, Aihara K, Watanabe S, Kayhanian H.
概要	Background: Prophylactic use of anticoagulants for septic patients in intensive care unit is a standard therapy for the prevention of venous thrombosis. Moreover, recent studies have demonstrated the anti-inflammatory effects of anticoagulants such as Factor Xa inhibitors and heparins. However, there have been no studies to examine the effects of fondaparinux and enoxaparin when applied in a sepsis model. Therefore, we examined the anti-inflammatory effects and bleeding events when these agents are applied in a lipopolysaccharide challenge model.Methods: Wistar rats received lipopolysaccharides followed by a bolus infusion of fondaparinux, enoxaparin, or placebo.