イワタ　シュウスケ   IWATA SHUSUKE   岩田　周介    所属   朝日大学  歯学部 口腔機能修復学講座 口腔生理学    朝日大学  大学院 歯学研究科    職種   講師
言語種別	英語
発行・発表の年月	2026/07
形態種別	研究論文
査読	査読あり
標題	Dissociation between amiloride-sensitive taste responses and ingestive behavior to sodium ascorbate in osteogenic disorder Shionogi rats
執筆形態	共著
掲載誌名	Chemical Senses
掲載区分	国外
著者・共著者	◎ Toshiaki Yasuo, Shinpei Takahashi, Shusuke Iwata, and Noritaka Sako
概要	Sodium ascorbate (AsA-Na) is widely used as a vitamin C source, but the mechanisms regulating its intake remain unclear. We examined behavioral and neural responses to AsA-Na in vitamin C synthesis-deficient ODS rats using two-bottle choice and short-term lick tests and chorda tympani (CT) nerve recordings. AsA-Na showed lower preference than NaCl, whereas lick responses were comparable to those for NaCl and increased during vitamin C deficiency. Intake of 10 mM AsA-Na selectively increased during vitamin C re-intake. The ENaC blocker amiloride strongly suppressed CT responses to AsA-Na but did not affect its long-term preference or intake. These results suggest that AsA-Na activates ENaC-dependent taste signaling, whereas its sustained intake is regulated by concentration- and nutritional state-dependent post-ingestive mechanisms rather than sodium taste signaling alone.