モリ　タイキ   MORI TAIKI   森　大気    所属   朝日大学  歯学部 口腔感染医療学講座 口腔微生物学    職種   助教
言語種別	英語
発行・発表の年月	2026/03
形態種別	研究論文（学術雑誌）
査読	査読あり
招待論文	招待あり
標題	LL-37 and bacterial DNA complexes in dental plaque: Implications for biofilm structure, innate immunity, and periodontal pathogenesis
執筆形態	共著
掲載誌名	Journal of Oral Biosciences
掲載区分	国外
巻・号・頁	68(2),pp.100771
著者・共著者	◎Tanabe G, Mori T, Hanaoka M, Domae E, Into T
概要	LL-37 binds to oral bacterial DNA forming stable, nuclease-resistant, high-molecular-weight complexes with an aggregated morphology. These complexes abrogate the intrinsic antimicrobial activity of LL-37 while enhancing the stability and cohesiveness of the biofilm matrix. Moreover, LL-37–bacterial DNA complexes act as immunostimulatory molecules by activating TLR9 and the NLRP3 inflammasome, thereby triggering proinflammatory cytokine production in host immune cells. Notably, this immunostimulatory capacity varies with the bacterial source of the DNA, suggesting species-specific modulation of host responses