ヤスオ　トシアキ   YASUO TOSHIAKI   安尾　敏明    所属   朝日大学  歯学部 口腔機能修復学講座 口腔生理学    朝日大学  大学院 歯学研究科    職種   講師
言語種別	英語
発行・発表の年月	2022/03
形態種別	研究論文
査読	査読あり
標題	Expression of taste signaling elements in jejunal tissue in subjects with obesity.
執筆形態	共著
掲載誌名	Journal of oral biosciences
掲載区分	国外
出版社・発行元	ELSEVIER
巻・号・頁	64(1),pp.155-158
担当区分	筆頭著者,責任著者
国際共著	国際共著
著者・共著者	◎Toshiaki Yasuo, G Craig Wood, Xin Chu, Peter Benotti, Christopher D Still, David D K Rolston, Robert F Margolskee, Yuzo Ninomiya, Peihua Jiang
概要	Taste-signaling proteins, which are expressed in the oral cavity and the gastrointestinal tract, may be involved in regulating metabolism and immunity via oral-gut-brain circuit. This study aimed to determine if these genes are expressed and altered in the jejunum of patients with extreme obesity after bariatric surgery. Reverse transcription polymerase chain reaction revealed that phospholipase C beta 2 and transient receptor potential channel M5 expressions were downregulated whereas Gustducins expression level remained unchained in the jejunum of patients with a body mass index >50. Our data suggest that taste-signaling dysregulation might contribute to obesity.
DOI	10.1016/j.job.2021.12.006.
researchmap用URL	https://researchmap.jp/Toshiaki_Yasuo/published_papers/36268623