ヤスオ　トシアキ   YASUO TOSHIAKI   安尾　敏明    所属   朝日大学  歯学部 口腔機能修復学講座 口腔生理学    朝日大学  大学院 歯学研究科    職種   講師
言語種別	英語
発行・発表の年月	2023/03
形態種別	研究論文（学術雑誌）
査読	査読あり
標題	Vitamin C Deficiency in Osteogenic Disorder Shionogi/Shi Jcl-od/od Rats: Effects on Sour Taste Preferences, Lick Rates, Chorda Tympani Nerve Responses, and Taste Transduction Elements
執筆形態	共著
掲載誌名	Chemical Senses
掲載区分	国外
出版社・発行元	OXFORD
巻・号・頁	48,pp.1-12
総ページ数	12
担当区分	筆頭著者,責任著者
著者・共著者	◎Yasuo T, Nakamura F, Suwabe T, and Sako N
原著者	Toshiaki Yasuo
概要	To investigate the response to sour taste substances during vitamin C (ascorbic acid; AA) deficiency, we conducted behavioral, neural, anatomical, and molecular biological experiments with osteogenic disorder Shionogi/Shi Jcl-od/od rats, which lack the ability to synthesize AA. Our data suggest that AA deficiency decreases avoidance of acids and reduces chorda tympani nerve responses to acids. AA deficiency downregulates some taste-related genes in fungiform papillae taste bud cells. However, the results also reveal that the mRNA expression of some putative sour taste receptors in fungiform papillae taste bud cells is not affected by AA deficiency.
DOI	10.1093/chemse/bjad008.