サトウ　ケイタロウ   SATOH KEITARO   佐藤　慶太郎    所属   朝日大学  歯学部 口腔感染医療学講座 歯科薬理学    朝日大学  大学院 歯学研究科    職種   教授
言語種別	英語
発行・発表の年月	2024/07
形態種別	研究論文（学術雑誌）
査読	査読あり
標題	Age-related alteration of the involvement of CD36 for salivary secretion from the parotid gland in mice
執筆形態	共著
掲載誌名	The journal of physiological sciences
掲載区分	国外
巻・号・頁	74(1),pp.38
担当区分	筆頭著者,責任著者
著者・共著者	◎Satoh K, Ohno Y, Nagase H, Kashimata M, Adachi K.
概要	This in vivo mouse model study was conducted to investigate the temporal alteration of the function of CD36 in salivary secretion. CD36 was highly expressed in the parotid gland of BALB/c mice. No significant variations were shown in the CD36 levels in the 8-, 48-, and 72-week-old animals. However, pilocarpine-induced salivary secretion was reduced in an age-dependent manner, showing a significantly low level at the age of 72 weeks. Pilocarpine-induced salivary secretion was significantly reduced by pretreatment with a CD36 inhibitor at 8 and 48 weeks, but not at 72 weeks. In senescence-accelerated mice (SAM), the pilocarpine-induced salivary secretion was significantly reduced at the age of 56 weeks, and a significantly lower amount of CD36 was demonstrated in the parotid gland, compared with the control. These results suggest that the involvement of parotid CD36 in mouse salivary secretion is altered with age.