イワセ　ヨウコ   IWASE YOKO   岩瀬　陽子    所属   朝日大学  歯学部 口腔病態医療学講座 障害者歯科学    朝日大学  大学院 歯学研究科    職種   教授
言語種別	日本語
発行・発表の年月	2016/09
形態種別	研究論文（学術雑誌）
標題	Tissue-specific stem cells obtained by reprogramming of non-obese diabetic (NOD) mouse-derived pancreatic cells confer insulin production in response to glucose
執筆形態	共著
掲載誌名	PLoS One
掲載区分	国外
担当範囲	細胞培養
著者・共著者	Saitoh I, Sato M, Soda M, Inada E, Iwase Y, Murakami T, Ohshima H, Hayasaki H, Noguchi H
概要	We showed that glucose-sensitive insulin-producing cells are successfully generated by transfecting primary pancreatic cells from NOD mice. Sixty-five days after final transfection, cobblestone-like colonies appeared. They proliferated in vitro and expressed pluripotency-related genes as well as Pdx1 for the β-cell lineage. Transplantation of these cells into nude mice failed to produce teratoma unlike induced pluripotent stem cells (iPSCs).