カミヤ　マサコ   KAMIYA MASAKO   神谷　真子    所属   朝日大学  保健医療学部救急救命学科 教養基礎講座    職種   教授
言語種別	英語
発行・発表の年月	2024/12
形態種別	研究論文（学術雑誌）
査読	査読あり
標題	Productions of Th2 cytokines, IL-4 and IL-10, were enhanced via the function of IL-2 from anti-CD3 antibody-stimulated mouse spleen cells treated with caffeic acid phenethyl ester
執筆形態	共著
掲載誌名	Journal of Oral Biosciences
掲載区分	国外
巻・号・頁	66(4),pp.34-40
著者・共著者	Moe Takahashi, Masako Mizuno-Kamiya, Shifa Rahman, Hanemi Tsuruta, Kumiko Ikeno, Harumi Kawaki, Genjiro Nakamura, Yasunori Muramatsu, Toru Nikaido, Hisakazu Fujita, Nobuo Kondoh
概要	CAPE treatment of anti-CD3 antibody-stimulated spleen cells reduced IFN-γ production, then enhanced IL-2 production, followed by enhancement of IL-4 and IL-10 production. The Th2 cytokine production enhancing effects of CAPE were completely abolished by addition of an anti-IL-2 neutralizing antibody. In the absence of CAPE, exogenously added IL-2 could enhance IL-4 production to a lesser degree, but did not stimulate IL-10 production, in stimulated spleen cells. Interestingly, CAPE significantly reduced the proportions of CD4+ and CD8+ cells, and increased those of CD4-CD8- cells among anti-CD3 stimulated spleen cells, in the presence or absence of anti-IL-2 neutralizing antibody treatment. Conclusion: CAPE reduced IFN-γ production, then enhanced IL-4 and IL-10 production via the activity of specifically elevated IL-2