ムラマツ　ヤスノリ   MURAMATSU YASUNORI   村松　泰徳    所属   朝日大学  歯学部 口腔病態医療学講座 口腔外科学    朝日大学  大学院 歯学研究科    職種   教授
言語種別	英語
発行・発表の年月	2018/12
形態種別	研究論文（学術雑誌）
査読	査読あり
標題	Gene expression analyses associated with malignant phenotypes of metastatic sub-clones derived from a mouse oral squamous cell carcinoma Sq-1979 cell line.
執筆形態	共著
掲載区分	国外
出版社・発行元	Oncol Lett.
巻・号・頁	15(03),pp.3350-3356
総ページ数	7
担当範囲	研究、論文作成の指導
著者・共著者	Adachi M, Mizuno-Kamiya M, Takayama E, Kawaki H, Inagaki T, Sumi S, Motohashi M, Muramatsu Y, Sumitomo S, Shikimori M, Yamazaki Y, Kondoh N.
概要	o elucidate the genetic events that occur during the development of OSCC, the present study established a model of oral malignancy using a mouse oral squamous cell carcinoma (OSCC) Sq-1979 cell line. Sq-1979 cells were implanted into syngeneic C3H mice. Subsequently, 233 cells and metastatic sub-clones (L cells) from primary OSCC, as well as the metastasized lymph node tissues of Sq-1979-implanted mice were established. Compared with parental Sq-1979 and 233 cells, the majority of L cells exhibited a higher proliferation rate and transplantability, and conferred a lower survival rate on the implanted mice. To investigate the genetic background of L cells, preferentially expressed genes in L cells were identified by cDNA microarray and reverse transcription-polymerase chain reaction analyses.