トモフジ　タカアキ   TOMOFUJI TAKAAKI   友藤　孝明    所属   朝日大学  歯学部 口腔感染医療学講座 社会口腔保健学    朝日大学  大学院 歯学研究科    職種   教授
言語種別	英語
発行・発表の年月	2018/10
形態種別	研究論文（学術雑誌）
標題	Impact of commensal flora on periodontal immune response to lipopolysaccharide
執筆形態	共著
掲載誌名	J Periodontol
掲載区分	国外
巻・号・頁	89(10),pp.1213-1220
著者・共著者	Tomofuji T
概要	The purpose of this study was to evaluate the expression of immune responses after topical application of LPS in germ-free (GF) and specific-pathogen-free (SPF) mice. SPF mice, but not GF mice, showed an increased number of CD4+ T cells in the periodontal tissue at 3 hours after LPS application, compared with the number at baseline (p < 0.05). Gene expressions of tumor necrosis factor-α (Tnf-α) and forkhead box protein p3 (Foxp3) was also significantly higher in the SPF mice than in the GF mice at 3 hours after LPS application (p < 0.05). The number of neutrophils peaked at 24 hours in both GF and SPF mice. LPS-exposed SPF mice exhibited increases in the number of CD4+ T cells and in Tnf-α and Foxp3 gene expression in periodontal tissue compared with LPS-exposed GF mice.
ISSN	0022-3492