トモフジ　タカアキ   TOMOFUJI TAKAAKI   友藤　孝明    所属   朝日大学  歯学部 口腔感染医療学講座 社会口腔保健学    朝日大学  大学院 歯学研究科    職種   教授
言語種別	英語
発行・発表の年月	2019/05
形態種別	研究論文（学術雑誌）
標題	Serum microRNAs and chronic periodontitis: A case-control study
執筆形態	共著
掲載誌名	Arch Oral Biol
掲載区分	国外
巻・号・頁	101,pp.57-63
著者・共著者	友藤　孝明
概要	An association is present between periodontitis and rates of expression of certain microRNAs (miRNAs) in periodontal tissue. We performed a case-control study in patients with chronic periodontitis to investigate serum miRNA levels. We enrolled 30 healthy patients without periodontitis and 30 patients with chronic periodontitis. Microarray demonstrated seven miRNAs that were expressed <1/1.5 or >1.5 in the control group compared to the periodontitis group (p < 0.05). Real-time PCR showed that hsa-miR-664a-3p, hsa-miR-501-5p, and hsa-miR-21-3p were higher in the periodontitis group than the control group (p < 0.05). Hsa-miR-664a-3p, hsa-miR-501-5p, and hsa-miR-21-3p are candidate serum biomarkers for chronic periodontitis.
ISSN	0003-9969
PMID	30889506