エハラ　ユウイチ   EHARA YUICHI   江原　雄一    所属   朝日大学  歯学部 口腔病態医療学講座 口腔外科学    朝日大学  大学院 歯学研究科    職種   講師
言語種別	英語
発行・発表の年月	2020/11
形態種別	記事・総説・解説・論説等（学術雑誌）
標題	Induction Chemotherapy for Cancer of Mandibular Gingival in a Patient with Solitary Kidney
執筆形態	共著
掲載誌名	Journal of Universal Surgery
掲載区分	国外
巻・号・頁	8
総ページ数	4
著者・共著者	Matsubara M1*, Ukai A1, Takahashi M1, Naganawa K1, Ehara Y1, Motohashi M2, Muramatsu Y1 and Sumitomo S1
概要	A 55-year-old Japanese woman was referred to us with a persistent pain in the left mandible that lasted for a few months. Her medical history included right nephrectomy after a traffic accident in childhood. An incisional biopsy revealed well-differentiated squamous cell carcinoma. The patient was diagnosed with stage G3a chronic kidney disease. She underwent two cycles of induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil. The cisplatin dose was reduced by 25%, but the docetaxel and 5-fluorouracil doses were not reduced. In both cycles, eGFR decreased, and serum creatinine transiently increased on Day 12; however, her renal function was restored at the end of each cycle. Then she underwent left mandibulectomy, buccal mucosa and partial maxillectomy, reconstructive surgery with a submental island flap. No infiltrative squamous cell carcinoma, sign of recurrence and aggravation of kidney function were observed.