オオノ　ミチヤ   OHNO MICHIYA   大野　道也    所属   朝日大学  歯学部 総合医科学講座 内科学（朝日大学病院）    職種   教授
言語種別	英語
発行・発表の年月	1999/08
形態種別	研究論文（学術雑誌）
標題	Lipoprotein(a)as a risk factor for coronary artery disease in hemodialysis patients
執筆形態	共著
掲載誌名	Kidney lnt
掲載区分	国外
巻・号・頁	56,pp.s42-s44
著者・共著者	HIROSHIGE OHASHI,HIROSHI ODA,MICHIYA OHNO,SACHIRO WATANABE,SIGEKI SAKATA
概要	More Abstract We studied whether lipoprotein(a) [Lp(a)] is an independent risk factor for coronary artery disease (CAD) in hemodialysis (HD) patients. A serum concentration of Lp(a) was measured in 212 patients with chronic glomerulonephritis and 56 patients with diabetic nephropathy (a total of 268 patients). The causes of death during five years of follow-up were studied and classified into either cardiovascular or noncardiovascular events. The mortality of these 268 HD patients during the observation period was 26.1%. Seventy-eight percent were due to cardiovascular events. Those who died of cardiovascular events had significantly higher serum Lp(a) levels than those died of noncardiovascular events. The relative risk of death from CAD was 0.71 in HD patients with a Lp(a) concentration above 30 mg/dl. This study indicates that the serum Lp(a) levels are independent indicators of the future risk of death from CAD in HD patients.