オオノ ミチヤ   OHNO MICHIYA
  大野 道也
   所属   朝日大学  歯学部 総合医科学講座 内科学(朝日大学病院)
   職種   教授
言語種別 英語
発行・発表の年月 2000/03
形態種別 研究論文(学術雑誌)
査読 査読あり
標題 T-0162 a novel free radical acavenger,reduces myocardial infarct size in rabbits.
執筆形態 共著
掲載誌名 Clin and Exp Pharmacol and Physiol
掲載区分国外
巻・号・頁 27,pp.172-178
著者・共著者 K.Yamashita,S.Minatoguchi,Y.Uno,T.Kariya,M.Ohno,M.Arai,K.Hashimoto,Y,Nishida,K.Nagashima,X.Qiu,G.Takemura,T.Suzuki,T.Fujiwara,H.Fujiwata
概要 We investigated the effects of 1-(3-tert-butyl-2-hydroxy- 5-methoxyphenyl)-3-(3-pyridylmethyl)urea hydrochloride (T-0162), a novel low-molecular weight free radical scavenger, on the generation of superoxide anions and hydroxyl radicals in vitro and in vivo and on myocardial infarct (MI) size in an in vivo model of MI in rabbits. In conclusion, T-0162 reduces MI size through the inhibition of reperfusion injury.