アズマ　テツジ   AZUMA TETSUJI   東　哲司    所属   朝日大学  歯学部 口腔感染医療学講座 社会口腔保健学    朝日大学  大学院 歯学研究科    職種   准教授
言語種別	英語
発行・発表の年月	2019/03
形態種別	研究論文（学術雑誌）
標題	Detection of salivary miRNAs reflecting chronic periodontitis: A pilot study
執筆形態	共著
掲載誌名	Molecules
掲載区分	国外
巻・号・頁	24(6),pp.1034
著者・共著者	Fujimori K,Yoneda T,Tomofuji T,Ekuni D,Azuma T,Maruyama T,Mizuno H,Sugiura Y,Morita M
概要	The purpose of this cross-sectional pilot study was to find salivary microRNAs (miRNAs) reflecting periodontal condition in chronic periodontitis. One hundred and twenty chronic periodontitis patients (mean age, 68.4 years) participated in the study, from whom unstimulated whole saliva was collected. Among 84 miRNAs, only the relative expression of hsa-miR-381-3p in the severe periodontitis group was significantly higher than that of the no/mild periodontitis group (p < 0.05). Among the 120 patients, there was also a significant correlation between the relative expression of hsa-miR-381-3p and the mean probing pocket depth (PPD) (r = 0.181, p < 0.05). Salivary hsa-miR-381-3p was correlated with periodontitis condition in chronic periodontitis patients.
ISSN	1420-3049