タジリカ　トシヒロ   TAJIRIKA TOSHIHIRO   田尻下　敏弘    所属   朝日大学  歯学部 総合医科学講座 外科学（朝日大学病院）    職種   准教授
発表年月日	2017/09
発表テーマ	Oncogenic RNA helicase DDX6 regulates post-transcriptional step of erbb2 expression in gastric cancer cells
会議名	第76回 日本癌学会
学会区分	国際学会
単独共同区分	共同
発表者・共同発表者	Toshihiro Tajirika, Yuki Kuranaga, Nobihiko Sugito, Haruka Shinohara, Yoshihisa Tokumaru, Kohei Taniguchi, Nobuhisa Matsuhashi, Takao Takahashi, Kazuya Yamaguchi, Manabu Futamura, Kazuhiro Yoshida, Yukihiro Akao
概要	Previously, we reported that the oncogenic RNA helicase DDX6 was overexpressed in most of malignant cell lines and clinical colorectal tumor samples through enhancement of c-Myc mRNA translational process. In the current study, we examined Gastric Cancer (GC) clinical samples by western blot analysis. RIP（RNP Immunoprecipitation）-assay in the GC cells indicate that DDX6 protein acts as RBP for erbb2 mRNAs and positively regulates the post-transcription process. These findings suggested that DDX6 may contribute to the pathogenesis of erbb2-positive GC through the promotion of erbb2 expression.