コンドウ　ノブオ   KONDO NOBUO   近藤　信夫    所属   朝日大学  歯学部 基礎教育系 化学    職種   教授
発表年月日	2021/04/10
発表テーマ	Augmented secretion of IL-1α from mouse oral squamous cell carcinoma (OSCC) cells caused by the serum deprivation and hypoxia promotes immune-suppressive activity of mesenchymal stromal cells.
会議名	AACR Annual meeting 2021
学会区分	国際学会
発表形式	ポスター
単独共同区分	共同
国名	アメリカ合衆国
開催期間	2021/04/10～2021/04/15
発表者・共同発表者	Kondoh N, Matsunami A, Mizuno-Kamiya M, Ando M, Umemura N, Takayama E, Kawaki H, Ueno K, Muramatsu Y, Morimoto-Ito H and Sumitomo S,
概要	Objectives; We have already reported that mouse oral squamous carcinoma (OSCC), Sq-1979-1, cells produce interleukin (IL) 1α which specifically enhances the immunosuppressive activity of co-cultured mesenchymal stromal, 10T1/2, cells. In this report, we evaluated conditions promoting the production of IL-1α of Sq-1979-1 cells, which could further enhance the immunosuppressive function of the 10T1/2 cells, and also evaluated the expression in OSCC tissues. Conclusions; IL-1α production by Sq-1979-1 cells was synergistically augmented in low serum and hypoxic conditions, which could promote immunosuppressive activity of mesenchymal cells.