ヤスオ　トシアキ   YASUO TOSHIAKI   安尾　敏明    所属   朝日大学  歯学部 口腔機能修復学講座 口腔生理学    朝日大学  大学院 歯学研究科    職種   准教授
発表年月日	2026/02/28
発表テーマ	Amiloride-Sensitive Taste Responses to Sodium Ascorbate and Post-Ingestive Suppression of Intake in Ascorbate-Replete ODS Rats
会議名	The 22th International Symposium on Molecular and Neural mechanisms of Taste and Olfactory Perception (ISMNTOP2025, /YRUF2025, AISCRIB2025)
学会区分	国際学会
発表形式	口頭（一般）
単独共同区分	共同
発表者・共同発表者	Toshiaki Yasuo, Shinpei Takahashi, Shusuke Iwata, Takeshi, Suwabe, Noritaka Sako
概要	ODS rats lacking ascorbic acid (AsA) synthesis show similar lick rates for sodium ascorbate (AsA-Na) and NaCl, suggesting a salt-like taste. However, reduced long-term intake of AsA-Na may involve post-ingestive effects. We examined preference and intake of AsA-Na and NaCl with or without amiloride (Ami), an ENaC inhibitor, and recorded chorda tympani responses. Ami reduced responses to 100 mM NaCl by ~45% and to AsA-Na by ~90%. Preference was unchanged, but intake of AsA-Na with Ami was lower. These results suggest AsA-Na taste is mediated via ENaC, while post-ingestive mechanisms suppress long-term intake.