ナガヤマ　モトヒコ   NAGAYAMA MOTOHIKO   永山　元彦    所属   朝日大学  歯学部 口腔病態医療学講座 口腔病理学    朝日大学  大学院 歯学研究科    職種   教授
発表年月日	2015/03
発表テーマ	Abnormal Chondrocyte Differentiation in Post-natal Cartilage Calcification Insufficient Rat
会議名	93rd General Session & Exhibition of the IADR/44th Annual Meeting of the AADR/39th Annual Meeting of the CADR
学会区分	国際学会
単独共同区分	共同
発表者・共同発表者	Motohiko Nagayama
概要	Contribution: Presenter, To determine whether Ihh regulates those processes during post-natal life, we studied these morphological characteristics of chondrocytes at cranial base synchondrosis and condylar cartilage of cartilage calcification insuficient (CCI) rats compared to normal SD rats.CCI rats showed abnormal synchondrosis including longitudinally wider length of intra-sphenoidal and spheno-occipital synchondrosis compared to the normal SD rats. CCI rats also exhibited morphological defects surface or reduced cartilage of mandibular condyle based of the histological and molecular biological findings. The data demonstrate that CCI rats affect their endochondral ossification due to excessive Ihh signaling, which results in hyper proliferating but feed-back arrest of chondrocyte differentiation to remain the layer of chondrocytes in post-natal development.