タカハシ　シンペイ   TAKAHASHI SHINPEI   髙橋　慎平    所属   朝日大学  歯学部 口腔機能修復学講座 口腔生理学    職種   助教
発表年月日	2026/02/28
発表テーマ	Amiloride-Sensitive Taste Responses to Sodium Ascorbate and Post-Ingestive Suppression of Intake in Ascorbate-Replete ODS Rats
会議名	The 22th International Symposium on Molecular and Neural mechanisms of Taste and Olfactory Perception (ISMNTOP2025, /YRUF2025, AISCRIB2025)
学会区分	国際学会
発表形式	口頭（一般）
単独共同区分	共同
開催地名	岡山県岡山市
開催期間	2026/02/28～2026/03/01
発表者・共同発表者	Toshiaki Yasuo, Shinpei Takahashi, Shusuke Iwata, Takeshi, Suwabe, Noritaka Sako
概要	ODS rats lacking ascorbic acid (AsA) synthesis show similar lick rates for sodium ascorbate (AsA-Na) and NaCl, suggesting a salt-like taste. However, reduced long-term intake of AsA-Na may involve post-ingestive effects. We examined preference and intake of AsA-Na and NaCl with or without amiloride (Ami), an ENaC inhibitor, and recorded chorda tympani responses. Ami reduced responses to 100 mM NaCl by ~45% and to AsA-Na by ~90%. Preference was unchanged, but intake of AsA-Na with Ami was lower. These results suggest AsA-Na taste is mediated via ENaC, while post-ingestive mechanisms suppress long-term intake.