タカハシ　シンペイ   TAKAHASHI SHINPEI   髙橋　慎平    所属   朝日大学  歯学部 口腔機能修復学講座 口腔生理学    職種   助教
発表年月日	2026/03/11
発表テーマ	The chorda tympani nerve responses and the behavioral responses to sugars were enhanced by Capsaicin via glucose transporter in mice
会議名	The 103rd Annual Meeting of The Physiological Society of Japan
学会区分	全国学会
発表形式	ポスター
単独共同区分	共同
開催地名	東京都新宿区
開催期間	2026/03/10～2026/03/12
発表者・共同発表者	Shusuke Iwata, Shinpei Takahashi, Toshiaki Yasuo, Takeshi Suwabe, Keiko Yasumatsu, Noritaka Sako, Yuzo Ninomiya
概要	This study examined whether capsaicin (CAP) influences taste-related ingestion behavior in mice. CAP activates the TRPV1 channel, but previous studies often used high concentrations that may cause TRPV1 desensitization. At a lower concentration (3 μM), CAP was previously shown to enhance chorda tympani nerve responses to sugars but not to artificial sweeteners. This effect occurred even in mice lacking the sweet receptor component T1R3 and was blocked by phlorizin, an inhibitor of the sodium/glucose cotransporter 1 (SGLT1), suggesting SGLT1 involvement. Here, a 10-s short-term lick test was used to determine whether adding 3 μM CAP, with or without phlorizin treatment, alters mice’s ingestion behavior toward various tastants.