イワタ　シュウスケ   IWATA SHUSUKE   岩田　周介    所属   朝日大学  歯学部 口腔機能修復学講座 口腔生理学    朝日大学  大学院 歯学研究科    職種   講師
発表年月日	2025/03/01
発表テーマ	Capsaicin enhances chorda tympani nerve and behavioral responses to sugars in mice
会議名	The 21th International Symposium on Molecular and Neural mechanisms of Taste and Olfactory Perception (ISMNTOP XXI, YRUF XXI, AISCRIB XIII)
学会区分	国際学会
発表形式	ポスター
単独共同区分	共同
国名	日本
開催期間	2025/03/01～2025/03/02
発表者・共同発表者	Shusuke Iwata, Toshiaki Yasuo, Shinpei Takahashi, Takashi Suwabe, Keiko Yasumatsu, Noritaka Sako, and Yuzo Ninomiya
概要	We found that the addition of 3 µM Capsaicin (CAP), a pungent component of chili peppers, enhanced the chorda tympani (CT) nerve responses to sugars (glucose, sucrose) but not to artificial sweeteners (SC45647) in wild type (C57BL6J/B6) mice. These effects also occurred in mice lacking the gene for sweet taste receptor component T1R3, and were abolished by the treatment with phlorizin, an inhibitor of sodium/glucose cotransporter 1 (SGLT1), a novel sweet taste receptor recently reported. It was expected that the CAP-induced enhancement of CT nerve responses to sugars are mediated by SGLT1, however, whether this enhancing effect of CT nerve responses to sugars actually affects the ingestion behavior for the sweet taste solution had not been investigated. In this study, we examined whether the addition of 3 µM CAP alters the ingestion behavior to various tastants in B6 mice by using a 10s short term rick test.