イワタ　シュウスケ   IWATA SHUSUKE   岩田　周介    所属   朝日大学  歯学部 口腔機能修復学講座 口腔生理学    朝日大学  大学院 歯学研究科    職種   講師
発表年月日	2025/03/17
発表テーマ	Effects of capsaicin on the chorda tympani nerve responses and the ingestive behavior for five basic tastes in mice.
会議名	AAPW2025(Anatomy-Physiology-Pharmacology Week in 2025)
学会区分	国際学会
発表形式	ポスター
単独共同区分	共同
国名	日本
開催地名	幕張メッセ
開催期間	2025/03/17～2025/03/19
発表者・共同発表者	Shusuke Iwata, Shinpei Takahashi, Toshiaki Yasuo, Takashi Suwabe, Keiko Yasumatsu, Noritaka Sako, and Yuzo Ninomiya
概要	CAP, a pungent component of chili peppers, stimulates the pain-receptive cation non-selective ion channel TRPV1 located at the trigeminal nerve terminal. In addition, there have been a wide variety of reports, including conflicting results in rodents. However, most of these reports used higher concetration, which induces TRPV1 desensitization, strongly suggesting a reproducibility problem in the measurement of taste sensitivities. We found 3 µM CAP, which is unlikely to induce TRPV1 desensitization, enhanced the CT nerve responses to sugars but not to artificial sweeteners in B6 mice. Therefore, it was expected that the CAP-induced enhancement of CT nerve response to sugar is mediated by SGLT1, but whether this enhancing effect actually affects the mice's ingestion behavior toward the taste solution had not been investigated.