アズマ　テツジ   AZUMA TETSUJI   東　哲司    所属   朝日大学  歯学部 口腔感染医療学講座 社会口腔保健学    朝日大学  大学院 歯学研究科    職種   准教授
発表年月日	2018/07/25
発表テーマ	Effect of coffee intake on oxidative stress in periodontal tissues
会議名	The 96th General Session of the IADR
単独共同区分	共同
発表者・共同発表者	Terumasa　Kobayashi,Tetsuji Azuma,Hisataka Miyai,Toshiki Yoneda,Takayuki Maruyama,Daisuke Ekuni,Takaaki Tomofuji,Manabu Morita
概要	In this study, we aimed to examine the effect of coffee intake, an antioxidant substance, on the increase in oxidative stress in periodontal tissue with aging. Male Fischer 344 rats (n=25, 8 weeks old) were divided into 3 groups: 0.63% coffee diet (group A, n = 8), 1.36% coffee diet (Group B, n = 9), and normal diet (C group, n = 8). The OXY adsorbent level was significantly higher in Group A and Group B than that in Group C (P <0.05). The number of 8-OHdG positive cells was significantly lower in group B than that in group C (P <0.05). The number of nuclear Nrf2 was significantly higher in group B than that in group C (P <0.05). Intake of coffee inhibited the increase in oxidative stress in periodontal tissues with aging through Nrf2/antioxidant defense pathway.