トモフジ　タカアキ   TOMOFUJI TAKAAKI   友藤　孝明    所属   朝日大学  歯学部 口腔感染医療学講座 社会口腔保健学    朝日大学  大学院 歯学研究科    職種   教授
発表年月日	2017/07/01
発表テーマ	Commensal flora affects osteoblasts mineralization in mice
会議名	Penn Periodontal Conference 2015
単独共同区分	共同
発表者・共同発表者	Tomofuji T
概要	Commensal flora affects the structure and immune status in periodontal tissue. Conventionally reared (SPF) mice exhibited the increase in the number of osteoclasts in alveolar bone and reduction in the alveolar bone height compared with those of germ-free (GF) mice. In contrast, no reports exist about the causal relationship between commensal flora and osteoblasts activity. The aim of this study was to investigate how commensal flora affects osteoblast activity in mice. In mice model, the results indicate that commensal flora could affected mineralization of osteoblasts modulating gene expression of RANKL/OPG ratio and osteocalcin.