スワベ　タケシ   SUWABE TAKESHI   諏訪部　武    所属   朝日大学  歯学部 口腔機能修復学講座 口腔生理学    朝日大学  大学院 歯学研究科    職種   准教授
発表年月日	2023/03/14
発表テーマ	Renin-angiotensin system in the geniculate ganglion of diabetic rats.
会議名	The 100th Anniversary Annual Meeting of The Physiological Society of Japan
学会区分	国際学会
発表形式	ポスター
単独共同区分	共同
開催地名	Kyoto
発表者・共同発表者	Takeshi Suwabe, Toshiaki Yasuo, Noritaka Sako, Shinpei Takahashi
概要	We hypothesized that diabetes activates renin-angiotensin system (RAS) in the geniculate ganglion containing taste a!erent neurons and changes the taste preference for glucose and sucrose. Adult male nondiabetic rats received a daily intraperitoneal injection of streptozotocin (STZ) for 2 days. Blood glucose levels of the STZ rats employed in this study was higher than 500 mg/dl. Geniculate ganglion was collected from rats, total RNA was extracted from the geniculate ganglion, and cDNA was synthesized from the RNA template by reverse transcription. Expression levels of RAS-related genes were determined by real-time PCR. Expression levels of angiotensinogen and angiotensin converting enzyme genes were higher in the STZ rats than in nondiabetic rats suggesting alteration of the RAS-related gene expression increases in taste preference for glucose and sucrose.