タカハシ　モエ   TAKAHASHI MOE   髙橋　萌    所属   朝日大学  歯学部 口腔病態医療学講座 口腔外科学    職種   助教
発表年月日	2021/10
発表テーマ	Artepillin C およびPPAR-γ阻害剤、GW9662による抗CD3抗体刺激マウス脾臓細胞のサイトカイン産生の修飾
会議名	歯科基礎医学会
主催者	歯科基礎医学会
学会区分	全国学会
発表形式	口頭（一般）
単独共同区分	共同
開催期間	2021/10/09
発表者・共同発表者	○Moe Takahashi1) , Masako Kamiya3), Kumiko Ikeno4) , Kyohei Ueno 2), Naoki Umemura2),  Harumi Kawaki2), Eiji Takayama2), Genjiro Nakamura4), Yasunori Muramatsu1), Nobuo Kondoh2)
概要	We have already reported that immune-modulatory effects upon activated T cells of Brazilian green propolis(BP) is mainly mediated by artepillin C, a major component of BP (Tsuruta H, et al). In this study, we used an antagonist, GW9662, against peroxisome proliferator-activated receptor (PPAR-γ), which is known as a receptor of artepillin C, and examined the direct or artepillin C-mediated indirect effect upon cytokine productions of anti CD3-antibody-stimulated mouse spleen cells. Our results demonstrated the production of IL-2, IL-4 and IL-10 by stimulated spleen cells were significantly enhanced, while that of IFN-γ, IL-6 and IL-17 were reduced by GW9662 treatments. These bilateral effects of GW9662 were further augmented in the presence of artepillin C. The synergistic effects of GW9662 on the cytokine regulations by artepillin C would suggest potential immune modulatory effects of this agent on BP.