コンドウ ノブオ
KONDO NOBUO
近藤 信夫 所属 朝日大学 歯学部 基礎教育系 化学 職種 教授 |
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発表年月日 | 2021/04/10 |
発表テーマ | Augmented secretion of IL-1α from mouse oral squamous cell carcinoma (OSCC) cells caused by the serum deprivation and hypoxia promotes immune-suppressive activity of mesenchymal stromal cells. |
会議名 | AACR Annual meeting 2021 |
学会区分 | 国際学会 |
発表形式 | ポスター |
単独共同区分 | 共同 |
国名 | アメリカ合衆国 |
開催期間 | 2021/04/10~2021/04/15 |
発表者・共同発表者 | Kondoh N, Matsunami A, Mizuno-Kamiya M, Ando M, Umemura N, Takayama E, Kawaki H, Ueno K, Muramatsu Y, Morimoto-Ito H and Sumitomo S, |
概要 | Objectives; We have already reported that mouse oral squamous carcinoma (OSCC), Sq-1979-1, cells produce interleukin (IL) 1α which specifically enhances the immunosuppressive activity of co-cultured mesenchymal stromal, 10T1/2, cells. In this report, we evaluated conditions promoting the production of IL-1α of Sq-1979-1 cells, which could further enhance the immunosuppressive function of the 10T1/2 cells, and also evaluated the expression in OSCC tissues.
Conclusions; IL-1α production by Sq-1979-1 cells was synergistically augmented in low serum and hypoxic conditions, which could promote immunosuppressive activity of mesenchymal cells. |