ヤスオ　トシアキ   YASUO TOSHIAKI   安尾　敏明    所属   朝日大学  歯学部 口腔機能修復学講座 口腔生理学    朝日大学  大学院 歯学研究科    職種   講師
発表年月日	2020/03/18
発表テーマ	The influence of body weight loss caused by vitamin C deficiency on the ingestive behavior in rats
会議名	The 97th Annual Meeting of the Physiological Society of Japan
学会区分	全国学会
発表形式	ポスター
単独共同区分	共同
開催地名	別府国際コンベンションセンター　B-CON PLAZA
発表者・共同発表者	Toshiaki Yasuo, Takeshi Suwabe, Noritaka Sako
概要	Vitamin C (VC) deficiency, called scurvy, causes body weight loss, anorexia, reduction of taste nerve responses, weakness, fatigue, depression, impaired wound healing, dysbasia, dental caries, dysfunctional dentine formation, gingivitis, and dry mouth. It is therefore important to understand how VC intake is controlled in annimals. To determine whether body weight loss influences VC intake in VC-deficient od/od rats or not, we conducted behavioral experiments using osteogenic disorder Shionogi/Shi Jcl-od/od (od/od>) rats, which lack the ability to synthesize VC, and their wild-type controls osteogenic disorder Shionogi/Shi Jcl- +/+ (+/+) rats. We found that the VC-deficient rats showed an increase in VC intake and a decrease in water intake; in contrast, body weight control rats showed a decrease in water intake but no change in VC intake. These data suggest that the change in VC intake displayed by VC-deficient rats cannot be accounted for by changes in body weight.