タツミ　ジュンイチ   TATSUMI JUNICHI   辰巳　順一    所属   朝日大学  歯学部 口腔感染医療学講座 歯周病学    朝日大学  大学院 歯学研究科    職種   教授
発表年月日	2020/11/06
発表テーマ	Effects of in LPS-induced chronic periodontitis mouse model
主催者	Amican Academy of Periodontology
学会区分	国際学会
発表形式	口頭（一般）
単独共同区分	共同
国名	アメリカ合衆国
開催地名	Virtual
開催期間	2020/11/06～2020/11/15
発表者・共同発表者	Hirotsugu Morinaga, Keiichi Kanayama, Toru Hasegawa, Takumi Sato, Mitsunobu Kitago, Junichi Tatsumi
概要	Alveolar bone resorption due to chronic inflammation is the main symptom of periodontitis. Conventional mouse periodontitis models require improvement as a model of chronic inflammation, particularly with respect to the method of inducing inflammation during the observation period. In this study, alveolar bone resorption was induced by a method which caused little mechanical irritation, and periodontitis progression in young and old mice was compared. LPS administration with a micro-syringe caused alveolar bone resorption in both young and old mice. In older mice, bone resorption was observed continuously in 4 weeks after LPS administration.